Abstract
Several 1,3-diaminocyclopentane linked alpha1a-receptor antagonists were prepared using a divergent chemical strategy that allows for rapid analysis of all stereochemical permutations for their effect on alpha1-receptor binding.
MeSH terms
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Adrenergic alpha-1 Receptor Antagonists*
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Adrenergic alpha-Antagonists / chemical synthesis*
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Adrenergic alpha-Antagonists / pharmacology
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Animals
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CHO Cells
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Cricetinae
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Humans
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Pyrimidinones / chemical synthesis*
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Pyrimidinones / pharmacology
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Receptors, Adrenergic, alpha-1 / metabolism
Substances
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Adrenergic alpha-1 Receptor Antagonists
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Adrenergic alpha-Antagonists
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Pyrimidinones
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Receptors, Adrenergic, alpha-1